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Newbain IM/IV Injection 20mg/2ml
Newbain Hydrochloride is indicated for:
- Relief of moderate to severe pain, including pain associated with myocardial infarction (MI).
- Supplement to balanced anesthesia.
- Preoperative and postoperative analgesia.
- Obstetrical analgesia during labor and delivery.
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✅ Description:
Pain is an unpleasant sensory experience triggered by stress, trauma, or external changes. Nalbuphine alleviates this sensation by addressing the underlying causes of pain.
Nalbuphine (Opioid Analgesic)
- Relief of severe pain.
- Pre- and post-operative analgesia as an adjunct to balanced anesthesia.
- Obstetrical analgesia during labor and delivery.
Nalbuphine functions by:
- Reducing the production of prostaglandins, which are inflammatory substances responsible for swelling and pain.
- Blocking pain-producing nerve transmitters decreases pain perception, and provides significant relief.
Nalbuphine must be administered by a qualified healthcare professional through intravenous (IV) or intramuscular (IM) injection. Self-administration is not recommended. Inform your doctor about any known allergies to Nalbuphine or its components.
- Nalbuphine is effective in managing labor pain and post-operative discomfort.
- Avoid combining with alcohol or other CNS depressants, as it may enhance sedative effects.
Inform the healthcare provider about any pre-existing medical conditions or ongoing medications.
Safety Advices
Alcohol
UNSAFE
You are advised not to take alcohol with Newbain as it might cause increased sedation and respiratory depression.
Pregnancy
CONSULT YOUR DOCTOR
Use with caution during pregnancy or lactation. Consult a doctor for guidance.
Breastfeeding
CONSULT YOUR DOCTOR
Use with caution during pregnancy or lactation. Consult a doctor for guidance.
Driving
UNSAFE
Avoid activities requiring alertness, such as driving or operating machinery, as Nalbuphine may cause drowsiness.
Kidney
CAUTION
Exercise caution before using Newbain in case of kidney problems. Please consult your doctor to address any concerns.
CAUTION
Exercise caution before using Newbain in case of established liver disease. Please consult your doctor to address any concerns.
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✔️ Uses of Newbain 20mg/2ml Injection
Treatment of Pain
✔️ How does Newbain 20mg/2ml Injection work?
Newbain 20mg/2ml Injection works by changing the way the brain and nervous system respond to pain.
✔️ Benefits of Newbain 20mg/2ml Injection
- Nalbuphine is an analgesic that is used as a painkiller for short-term management of severe pain.
- Nalbuphine blocks pain signals, so the brain doesn't perceive the severity of pain, hence increasing the body's threshold for pain.
- Nalbuphine may also be used as an adjunct to balanced anesthesia for pre/post-operative analgesia, during labor and delivery.
✔️ Side Effects of Newbain 20mg/2ml Injection
Generally well-tolerated but may include:
- Common: Sedation, nausea, vomiting, dizziness, sweating, dry mouth.
- Rare: Headache, respiratory depression, asthma, dyspnea.
✔️ Indication of Newbain 20mg/2ml Injection
Newbain is an opioid pain medicine used to relieve moderate to severe pain. It is also used with other medications to relieve pain before, during, or after surgery and other medical procedures.
✔️ Pharmacology
- Mechanism of Action:
- Nalbuphine is a synthetic potent analgesic, equivalent in potency to morphine.
- Acts as a kappa agonist and a partial mu antagonist.
- Onset of Action:
- Intravenous: 2-3 minutes.
- Subcutaneous/Intramuscular: <15 minutes.
- Duration: 3 to 6 hours.
- Half-life: Approximately 5 hours.
✔️ Dosage & Administration of Newbain 20mg/2ml Injection
Moderate to Severe Pain:
- Adults: 10–20 mg IV/IM for a 70 kg individual, repeat every 3–6 hours as needed.
- Children: 0.3 mg/kg IV/IM, repeated as necessary.
Preoperative Anesthesia:
- 0.1–0.2 mg/kg IV/IM.
Obstetrical Analgesia (Labor & Delivery):
- 0.3–1 mg/kg IV over 10–15 minutes, with maintenance doses of 0.25–0.5 mg/kg as required.
Intraoperative Analgesia:
- 0.25–0.5 mg/kg IV at 30-minute intervals.
Myocardial Infarction:
- 10–20 mg IV slowly, repeated after 30 minutes if necessary.
Children (18 months to 15 years):
- 0.2 mg/kg IV/IM, maintenance doses every 4–6 hours as required.
✔️ Interaction
- Additive CNS Effects: When combined with:
- Narcotic analgesics.
- General anesthesia.
- CNS depressants (e.g., alcohol, sedatives, tranquilizers).
✔️ Contraindications
Hypersensitivity to Nalbuphine Hydrochloride.
✔️ Pregnancy & Lactation
- Pregnancy Category B: Use only if needed.
- Minimal excretion in breast milk, with negligible effects.
✔️ Precautions & Warnings
- Use cautiously in:
- Impaired respiratory, renal, or hepatic function.
- Post myocardial infarction.
- Biliary tract surgeries.
- Can cross the placenta and is excreted in small amounts in breast milk.
✔️ Storage:
- Store below 30°C, protected from light.
- Keep out of reach of children.
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